王咸文

王咸文，安徽医科大学教授，博士生导师，东南博士后合作导师。安徽医科大学校学术委员会委员，中国生物材料学会烧创伤创面修复材料分会第二届委员会委员。科睿唯安全球高被引科学家（2024/2025），安徽省优青（2024），安徽省青年拔尖人才（2024），安徽省教育厅优青（2023），校优秀青年人才（2025）。入选斯坦福全球顶尖2%科学家2022-2025年榜单，安徽省D类高层次人才（2024），Nanoscale/Journal of Materials Chemistry B/ Biomaterials Science等国际期刊的Emerging Investigators（新锐科学家）。主持国自然面上、青年基金、安徽省优青和安徽省自然基金等在内的10余项课题。获安徽省科学技术奖三等奖和安徽省教学成果奖一等奖各1项。是Nano TransMed执行主编和BIO Integration副主编，Exploration和Cancer Nanotechnology等期刊编委。主要从事烧伤创面、细菌感染与组织再生方面的研究。以第一作者/通讯作者在Cell Biomaterials，Chemical Society Reviews、Journal of the American Chemical Society、Advanced Materials、Advanced Functional Materials、ACS Nano、Biomaterials等在内的材料和生物医学领域的国际知名期刊上发表IF大于10分以上的论文60余篇。论文总次数超过12000余次，其中ESI高被引论文20篇，热点论文1篇，H-index：55。申请人的研究成果先后受到搜狐网和中国科学报等众多媒体和网站的亮点报道，多篇文章被选为封文。

科研项目：

1. 国家自然科学基金面上项目，多功能 CuFeO_x纳米酶在烧伤创面治疗中的应用探索及机制研究，2024.1-2027.12，49万元在研，主持

2. 国家自然科学基金青年项目，巨噬细胞外泌体膜包被的仿生Cu-TiO_2-x声敏剂的构建及其在脑胶质瘤中的协同治疗研究，2023.1-2025.12，30万，已结项，主持

3. 安徽省自然科学基金优秀青年项目，纳米酶的构建及其生物医学应用，2024.9-2027.8，20万元，在研，主持

4.安徽省高校优秀青年科研项目，生物医用材料的设计与构建，2023.9-2026.8，50万元，在研，主持

5. 安徽省自然科学基金青年项目，具有多酶活性的CuMnO_x纳米球在细菌感染治疗中的应用探索及其机制研究，2022.1-2024.12，10万元，已结项，主持

6. 校优秀青年人才专项支持经费, 2025.9-2028.9，120万元，在研，主持

奖励：

1. 安徽省教学成果奖一等奖（2024）

2. 安徽省科学技术奖三等奖（2024）

3. 安徽医科大学优秀青年人才（2025）

4. 安徽医科大学 2023年度十佳论文（十大科技亮点）

5. 安徽医科大学2023年度復元科技新星

近五年代表性成果：

1. Xianwen Wang, Xiaoyan Zhong, Lixin Bai, Jun Xu, Fei Gong, Ziliang Dong, Zhijuan Yang, Zhijie Zeng, Zhuang Liu, Liang Cheng*. Ultrafine titanium monoxide (TiO_1+x) nanorods for enhanced sonodynamic therapy. Journal of the American Chemical Society, 2020, 142, 6527-6537. (中科院一区 IF: 16.383, TOP 期刊，ESI高被引论文)

2. Wenqi Wang, Hengshuo Gui, Xiaolong Wei, Huiyu Liu*, Xianwen Wang*. Cuproptosis to Cuproptosis-Like: Therapeutic Strategies for Bacterial Infection. Advanced Materials, 2025, 2506119. (中科院一区 IF: 26.8，TOP 期刊)

3. Ying Zang, Wei Zhang, Wenqi Wang, Xinyu Zhao, Xianwen Wang*. TiO/CIP/SilMA hydrogels promote the repair of infected wounds by interfering with bacterial signaling and energy metabolism. Cell Biomaterials, 2025, DOI: 10.1016/j.celbio.2025.100217.（Cell子刊）

4. Yuyu Cui, Qiang Niu, Zhiyuan Hu, Min Wang*, Xu-Lin Chen*, Xianwen Wang*. Multifunctional nanozyme-hydrogel system in bacterial-infected wounds. Cell Biomaterials, 2025, 100074.（Cell子刊）

5. Xianwen Wang, Xiaoyan Zhong, Jianxiang Li, Zhuang Liu*, and Liang Cheng*. Inorganic nanomaterials with rapid clearance for biomedical applications. Chemical Society Reviews, 2021, 50, 8669-8742. (中科院一区 IF: 60.615，TOP 期刊)

6. Wenqi Wang, Xiaolong Wei, Bolong Xu, Hengshuo Gui, Yan Yan*, Huiyu Liu*, Xianwen Wang*. Copper Single-Atoms Loaded on Molybdenum Disulphide Drive Bacterial Cuproptosis-Like Death and Interrupt Drug-Resistance Compensation Pathways. Nano-Micro Letters, 2025, DOI:10.1007/s40820-025-01955-2. (中科院一区 IF:36.3，TOP 期刊)

7. Jianguo Niu, Yuhao Xue, Wenqi Wang, Wei Zhang, Min Wang, Jiaqi Qin, Dongliang Yang*, Xianwen Wang*. Engineering a Gram-Negative Bactericidal Hydrogel: Cu_xTe Nanozyme Functions as a Specific Killer by Hijacking LPS and Flagella Biosynthesis. Research, 2026, DOI: 10.34133/research.1140. (中科院一区 IF: 10.9，TOP 期刊)

8. Zhiyuan Hu^#, Jie Shan^#, Xu Jin, Weijie Sun, Liang Cheng, Xulin Chen*, Xianwen Wang*. Nanoarchitectonics of in situ antibiotic-releasing acicular nanozymes for targeting and inducing cuproptosis-like death to eliminate drug-resistant bacteria. ACS Nano, 2024, 18, 24327-24349. (中科院一区 IF: 15.8，TOP 期刊)

9. Wenqi Wang^#, Yuyu Cui^#, Xiaolong Wei, Ying Zang, Liang Cheng, Xulin Chen, Xianwen Wang*. CuCo₂O₄ nanoflowers with multiple enzyme activities for treating bacterium-infected wounds via cuproptosis-like death. ACS Nano, 2024, 18, 15845-15863. (中科院一区 IF: 15.8，TOP 期刊)

10. Zhengwan Jiang^#, Wei Zhang^#, Can Zhu, Zhiyuan Hu, Xinjian Xiang, Dongsheng Cao*, Xianwen Wang*. Copper Telluride@Sodium Alginate-Poly(vinyl Alcohol) Nanofiber/Gauze Wound Dressing for Gram-Negative Bacteria-Infected Wounds. ACS Nano, 2025, 19, 26170-26192. (中科院一区 IF: 15.8，TOP 期刊)

11. Erxu Tao, Yiwei Sun, Yaxin Liu, Cailiang Shen, Yuanyin Wang*, Xianwen Wang*. Elesclomol-Loaded Cuprous Oxide Nanozymes with Dual-Enzyme Activities for Implant-Related Infection Therapy by Enhancing Bacterial Cuproptosis-Like Death. Advanced Functional Materials, 2026, e24044. (中科院一区 IF: 19，TOP 期刊) 

12. Wei Zhang, Qiang Niu, Yuyu Cui, Kelong Fan, Xianwen Wang*. Copper-Doped Prussian Blue Nanozymes: Targeted Starvation Therapy Against Gram-Positive Bacteria via the ABC Transporter Inhibition. Advanced Functional Materials, 2025, e07939. (中科院一区 IF: 19，TOP 期刊)

13. Yiwei Sun, Wei Zhang, Zhiwen Luo, Can Zhu, Yiqun Zhang, Zheng Shu, Cailiang Shen, Xiaxi Yao*, Yuanyin Wang*, and Xianwen Wang*. ZnO-CuS/F127 Hydrogels with Multienzyme Properties for implant-related infection therapy by inhibiting bacterial arginine biosynthesis and promoting tissue repair. Advanced Functional Materials, 2024, 2415778. (中科院一区 IF: 19，TOP 期刊)

14. Siyu Gui, Weiwei Tang, Zhihao Huang, Xinchen Wang, Siyin Gui, Xiang Gao, Duncheng Xiao, Liming Tao, Zhengxuan Jiang*, Xianwen Wang*. Ultrasmall Coordination Polymer Nanodots Fe-Quer Nanozymes for Preventing and Delaying the Development and Progression of Diabetic Retinopathy. Advanced Functional Materials, 2023, 33, 2300261. (中科院一区 IF: 19，TOP 期刊)

15. Xinting Feng, Zhiwen Luo*, Wei Zhang, Renwen Wan, Yisheng Chen, Fangqi Li, Yanwei He, Zhiheng Lin, James Hoipo Hui, João Conde, Shiyi Chen*, Zhijie Zhao*, Xianwen Wang*. Zn-DHM Nanozymes Enhance Muscle Regeneration Through ROS Scavenging and Macrophage Polarization in Volumetric Muscle Loss Revealed by Single-Cell Profiling. Advanced Functional Materials, 2025, 202506476. (中科院一区 IF: 19，TOP 期刊)

16. Xueting Guo^#, Wei Zhang^#, Can Zhu^#, Ying Zang, Wenqi Wang, Xu-Lin Chen, Liang Cheng, Xianwen Wang*. MnO₂-Pd/PAAS hydrogels with OXD-like and SOD-like dual enzymatic activities accelerate infected wound healing by inhibiting bacterial growth and mitigating oxidative stress. Advanced Functional Materials, 2025, accepted. (中科院一区 IF: 19，TOP 期刊)

17. Haojie Ge, Min Wang, Haijiao Xie, Xu-Lin Chen*, Xianwen Wang*. Phenylboronic Acid-Modified Copper Nanozymes as Nanoscavengers of Bacterial Polysaccharides Causing Acute Lung Injury. Advanced Science. 2025, e13536. (中科院一区 IF: 14.3，TOP 期刊)

18. Yiqun Zhang^#, Ni Zhang^#, Jianghao Xing^#, Yiwei Sun, Xu Jin, Cailiang Shen, Liang Cheng, Yuanyin Wang*, Xianwen Wang*. In situ hydrogel based on Cu-Fe₃O₄ nanoclusters exploits oxidative stress and the ferroptosis/cuproptosis pathway for chemodynamic therapy. Biomaterials, 2024, 311, 122675. (中科院一区 IF: 12.8，TOP 期刊）

19. Dongdong Liu^#, Xingliang Dai^#, Wei Zhang, Xuyang Zhu, Zhengbao Zha, Haisheng Qian, Liang Cheng, and Xianwen Wang*. Liquid exfoliation of ultrasmall zirconium carbide nanodots as a noninflammatory photothermal agent in the treatment of glioma. Biomaterials, 2023, 292, 121917. (中科院一区 IF: 12.8，TOP 期刊)

20. Xinyu Zhao^#, Shuo Zhang^#, Min Wang, Qingrong Li, Xiaolong Wei, Xu-Lin Chen*, Xianwen Wang*. Cu-DHM nanozymes treat flap ischemia-reperfusion injury by amplifying immune modulation in a cascade manner and inhibiting cell apoptosis. Bioactive Materials, 2025, 51, 720-739. (中科院一区 IF: 20.3)

21. Shuo Zhang^#, Xinyu Zhao^#, Wei Zhang, Xiaolong Wei, Xu-Lin Chen*, Xianwen Wang*. Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy. Bioactive Materials, 2025, 49, 63-84. (中科院一区 IF: 20.3)

22. Xianwen Wang^#, Qianqian Shi^#, Zhengbao Zha*, Dongdong Zhu, Lirong Zheng, Luoxiang Shi, Xianwen Wei, Lian Lian, Konglin Wu*, Liang Cheng*. Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy. Bioactive Materials, 2021, 6, 4389-4401. (中科院一区 IF: 18.0，TOP 期刊)

23. Jie Shan^#, Xu Jin^#, Cong Zhang^#, Muchen Huang^#, Jianghao Xing, Qingrong Li, Yuyu Cui, Qiang Niu, Xulin Chen*, Xianwen Wang*. Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria. Acta Pharmaceutica Sinica B, 2024, 657, 2211-3835. (中科院一区 IF:14.7，TOP 期刊)

24. Xinyu Zhao^#, Jie Shan^#, Xu Jin^#, Yiwei Sun, Jianghao Xing, Qingrong Li, Xulin Chen*, Xianwen Wang*. Caffeic acid-vanadium nanozymes treat skin flap ischemia‒reperfusion injury through macrophage reprogramming and the upregulation of X-linked inhibitors of apoptotic proteins. Acta Pharmaceutica Sinica B, 2024, 15, 592-610. (中科院一区 IF:14.7，TOP 期刊)

联系方式：

E-mail：xianwenwang@ahmu.edu.cn 

地址：安徽省合肥市安徽医科大学东校区生物医学工程学院