邵伟

邵伟，男，博士，安徽医科大学口腔医学院双聘教授，基础医学院教授，博士生/硕士生导师，东南博士后合作导师。安徽省“百人计划”入选者，安徽省优秀青年研究生导师，安徽省引进高层次人才奖补获得者。安徽省C类高层次人才，合肥市C类高层次人才，江淮优才卡（C类）获得者。安徽医科大学首届復元科技新星。安徽医科大学基础医学院学术分委会委员。第一届中国药理学会抗炎免疫专委会委员、青年委员会常务委员。中国科学院上海生命科学研究院博士，美国加州大学旧金山分校（UCSF）医学院风湿免疫系博士后。

主要从事RNA加工与人类疾病、自身免疫以及牙周炎发生发展分子机制相关研究；主持国家自然科学基金项目2项，省部校级课题6项，省级教学研究项目3项。以第一或通讯作者（含共同）在Nucleic Acids Research, Molecular and Cellular Biology, RNA, Journal of Biological Chemistry, Journal of Immunology等期刊发表论文25篇（中科院1区5篇，中科院二区16篇）。论文在领域内取得较大影响力，其中论文“A U1-U2 snRNP Interaction Network during Intron Definition”被知名论文评价网站F1000推荐阅读。发表于知名期刊Nucleic Acids Research杂志的论文，被审稿人及编辑共同推荐以“突破性研究论文（Breakthrough Article）”（占所有发文量的1-3%）形式发表。指导培养学生获国家奖学金，安徽省优秀毕业研究生，三好研究生，“明德·力行”交流合作奖学金，省级大学生创新创业项目等多项荣誉。

科研项目：

1. ZC3H13介导Git2可变剪接在巨噬细胞炎症反应中的作用与机制研究，安徽省自然科学基金面上项目（2508085MH205），2025.09-2028.08，8万元。

2. 自身免疫调节因子AIRE通过上调HEXIM1促进T细胞中枢免疫耐受的机制研究，国家自然科学基金面上项目（82071770），2021.01-2024.12，55万元。

3. 子痫前期早期预测以及非编码RNA在其发病机制中的作用研究（2017zhyx09），安徽省转化医学研究院科研基金项目，2018.01-2020.12。

4. AIRE调控细胞凋亡机制研究(KJ2017A190). 安徽高校自然科学研究重点项目，2017.1-2018.12，6万元。

5. AIRE调控HEXIM1促进中枢免疫耐受机制研究（XJ201601）。安徽医科大学博士科研资助，2017.1-2021.12

6. RNA解旋酶Prp5的翻译后修饰及其调控剪接机制研究(31400653). 国家自然科学基金青年科学基金项目，2015.1-2017.12，25万元。

发表论文：

1、Wang Y, ZhanC, Zhang Y, Li X, Mei, L, Yang B, Shao M and Shao W*. Silencing of Zc3h13 attenuates LPS-induced inflammatory response in macrophages via m6A-dependent stabilization of Spic mRNA. Journal of Immunology. 2026. dio:10.1093/jimmun/vkag034. （中科院3区，影响因子3.9）

  2、Wu E, Zhuo Q, Yin X, Li J, Zhang H, Gu F, Liang F, Zhou X, Gao Z, Li B*, Wang Q*, Shao W*.Single-cell and bulk transcriptomic analyses reveal PANoptosis-associated immune dysregulation of fibroblasts in periodontitis. Front Immunol. 2025 Sep 5;16:1671919. doi: 10.3389/fimmu.2025.1671919. PMID: 40977731; PMCID: PMC12446042. （中科院2区，影响因子5.9）

3、Wang X, Liu W, Zhan C, Zhang Y, Li X, Wang Y, Sheng M, Maqsood M, Shen H, Liang A, Shao W*. Alternative splicing of EZH2 regulated by SNRPB mediates hepatocellular carcinoma progression via BMP2 signaling pathway. iScience. 2024 Dec 18;28(1):111626. doi: 10.1016/j.isci.2024.111626. PMID: 39850359; PMCID: PMC11754826. （中科院2区，影响因子4.6）

4、Zhang Y, Zhan C, Mei L, Li X, Liu W, Sheng M, Wang Y, Zhao Q, Zhang L, Shao M, Shao W*. Silencing of lncRNA Gm26917 Attenuates Alveolar Macrophage-mediated Inflammatory Response in LPS-induced Acute Lung Injury Via Inhibiting NKRF Ubiquitination. Inflammation. 2025 Jan 18. doi: 10.1007/s10753-025-02240-5. Epub ahead of print. PMID: 39825194. （中科院2区，影响因子5.0）

5、Liu X, Zhang L, Chen J, Shao W*. Decoding intricate interactions between m6A modification with mRNAs and non-coding RNAs in cervical cancer: Molecular mechanisms and clinical implications. Cell Signal. 2025 Jul;131:111745. doi: 10.1016/j.cellsig.2025.111745. Epub 2025 Mar 17. PMID: 40107480. （中科院2区，影响因子4.4）

6、Wu E, Yin X, Liang F, Zhou X, Hu J, Yuan W, Gu F, Zhao J, Gao Z, Cheng M, Yang S, Zhang L, Wang Q*, Sun X*, Shao W*. Analysis of immunogenic cell death in periodontitis based on scRNA-seq and bulk RNA-seq data. Front Immunol. 2024 Nov 1;15:1438998. doi: 10.3389/fimmu.2024.1438998. PMID: 39555084; PMCID: PMC11568468. （中科院2区，影响因子5.7）

7、Wu E, Gu F, Zhuo Q, Gao Z, Zhang Y, Li J, Yin X, Bao W, Zhou X, Liang F, Yang S, Wang Y*, Wang Q* and Shao W* (2025) Exploration the role of pro-inflammatory fibroblasts and related markers in periodontitis: combing with scRNA-seq and bulk-seq data. Front. Immunol. 16:1537046. doi: 10.3389/fimmu.2025.1537046（中科院2区，影响因子5.9）

8、Wu E, Cheng M, Zhang X, Wu T, Sheng S, Sheng M, Wei L, Zhang L*, Shao W* (2024). Exploration of potential shared gene signatures between periodontitis and multiple sclerosis. BMC Oral Health. 2024 Jan 13;24(1):75. (影响因子2.9，中科院2区).

9、Chen B^#, Han Y^#, Sheng S^#, Deng J^#, Vasquez E, Yau V, Meng M, Sun C, Wang T, Wang Y, Sheng M, Wu T, Wang X, Liu Y, Lin N*, Zhang L*, Shao W* (2023). An angiogenesis-associated gene-based signature predicting prognosis and immunotherapy efficacy of head and neck squamous cell carcinoma patients. J Cancer Res Clin Oncol. 2024 Feb 12;150(2):91. (影响因子3.7，中科院3区)

10、Sheng M, Zhang Y, Wang Y, Liu W, Wang X, Ke T, Liu P, Wang S, Shao W* (2023). Decoding the role of aberrant RNA alternative splicing in hepatocellular carcinoma: a comprehensive review. J Cancer Res Clin Oncol. 2023 Dec;149(19):17691-17708. (影响因子3.7，中科院3区)

11、Zhang L, Sheng M, Cao H, Zhang L*, Shao W* (2023). Decoding the role of long non-coding RNAs in periodontitis: A comprehensive review. Biomed Pharmacother. 2023 (影响因子7.5，中科院1区)

12、Jin J, Liu XM, Shao W*, Meng XM*. (2024) Nucleic acid and protein methylation modification in renal diseases. Acta Pharmacol Sin. 2024 Apr;45(4):661-673. (影响因子8.2，中科院1区)

13、Li XY, Yu JT, Dong YH, Shen XY, Hou R, Xie MM, Wei J, Hu XW, Dong ZH, Shan RR, Jin J, Shao W*, Meng XM*. (2023) Protein acetylation and related potential therapeutic strategies in kidney disease. Pharmacol Res. 2023 Nov;197:106950. (影响因子9.5，中科院1区)

14、Zhao Q, Sheng M-F, Wang Y-Y, Wang X-Y, Liu W-Y, Zhang Y-Y, Ke T-Y, Chen S, Pang G-Z, Yong L, Ding Z, Shen Y-J, Shen Y-X and Shao W* (2022) LncRNA Gm26917 regulates inflammatory response in macrophages by enhancing Annexin A1 ubiquitination in LPS-induced acute liver injury. Frontiers in Pharmacology 13:975250. doi: 10.3389/fphar.2022.975250 （影响因子5.988，中科院2区）。

15、Ni WJ, Lu H, Ma NN, Hou BB, Zeng J, Zhou H, Shao W*, Meng XM* (2022). RNA N6 -methyladenosine modifications and potential targeted therapeutic strategies in kidney disease. Br J Pharmacol. 2023 Jan;180(1):5-24. doi: 10.1111/bph.15968. Epub 2022 Oct 24. PMID: 36196023. （影响因子9.473，中科院1区）。

16、Chen B, Yao Y, Mao D, Li C, Wang X, Sheng S, Zhang L, Wang X, Chen S, Xu W, Deng J, Sun C, Zhou Q, Lowe S, Bentley R, Shao W* and Li H* (2022) A Signature Based on Costimulatory Molecules for the Assessment of Prognosis and Immune Characteristics in Patients With Stomach Adenocarcinoma. Frontiers In Immunology 13:928742. doi: 10.3389/fimmu.2022.928742（影响因子8.786，中科院2区）

17、Xu RY, Ding Z, Zhao Q, Ke TY, Chen S, Wang XY, Wang YY, Sheng MF, Wang W, Long N, Shen YX, Xu YZ, Shao W*. An Alternatively Spliced Variant of METTL3 Mediates Tumor Suppression in Hepatocellular Carcinoma. Genes. 2022; 13(4):669. （影响因子4.141，中科院3区）

18、Zhao Q, Pang G, Yang L, Chen S, Xu R, Shao W*. Long Noncoding RNAs Regulate the Inflammatory Responses of Macrophages. Cells. 2022;11(1):5（影响因子7.666，中科院2区）

19、Xu RY^#, Pang GZ^#, Zhao Q, Yang L, Chen S, Jiang L, Shen YX*, Shao W*. The momentous role of N6-methyladenosine in lung cancer. Journal of Cellular Physiology 2021;236(5):3244-3256（影响因子6.384，中科院2区）

20、Shao W, Ding Z, Zheng ZZ, Shen JJ, Shen YX, Pu J, Fan YJ., Query CC, and Xu YZ. Prp5−Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription

Nucleic Acids Research (2020), 48(11):5799-5813（Breakthrough Article, 影响因子16.971，中科院1区）

21、Shao W., Zumer, K., Fujinaga, K., Peterlin, BM. (2016) FBXO3 Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). Journal of Biological Chemistry, 291(34):17953-63. (影响因子4.258，中科院2区)

22、Eifler, T., Shao W., Bartholomeeusen, K., Fujinaga, K., Jäger, S., Johnson J., Luo, ZP., Krogan, N., and Peterlin, BM. (2015) CDK12 increases 3’end processing of growth factor-induced c-FOS transcripts. Molecular and Cellular Biology 35(2):468-78 (co-first author，影响因子5.614，中科院2区)

23、Shao W., Zhao, QY., Wang, XY., Xu, XY., Tang, Q., Li, M., Li, X. and Xu, YZ.

(2012) Alternative splicing and trans-splicing events revealed by analysis of the

Bombyx mori transcriptome. RNA 18:1395-407. (影响因子6.051，中科院2区)

24、Shao W., Kim, HS., Cao, Y., Xu, YZ. and Query, CC. (2012) A U1–U2 snRNP interaction network during intron definition. Molecular and Cellular Biology32:470-478. (影响因子6.188，中科院2区 Highlight by F1000. http://f1000.com/prime/13364996)

25、Shao W., Fan YJ., Xu, YZ. (2010) Function of SR protein family in pre-mRNA splicing, Chinese Bulletin of Life Sciences 22: 710-716 (invited review, In Chinese)

联系方式：

E-mail: ShaoWei@ahmu.edu.cn

地址：安徽省合肥市安徽医科大学口腔医学院