崔昊

崔昊，男，安徽医科大学药学科学学院校聘副教授，硕士研究生导师。2022年毕业于中国药科大学获药物化学博士学位。

主要研究方向为小分子药物的设计、合成及生物活性研究。主持国家自然科学基金青年项目1项，并参与多项国家和省级自然科学基金。目前已在J Med Chem, Eur J Med Chem等专业期刊发表SCI论文12篇，申请专利3项。

科研项目：

1. 国家自然科学基金青年基金项目（C类），82504597，2026/1-2028/12，30万元，在研，主持；

2. 安徽省高校自然科学研究项目，2022AH050654，2023/1-2024/12，结题，主持。

近五年代表性论文：

1. Hao Cui*, Xu Huang, Rui Li, Meng Zong, Shilong Sun, Hongmei Li, Yadong Chen, Tao Lu*, Yong Zhu*. Design and Synthesis of Novel N-(1H-pyrazol-3-yl)pyrimidin-4-amine Aurora/HDAC Dual Inhibitors for Colorectal Cancer Treatment. . Journal of Medicinal Chemistry. 2025, 68(22): 23941-23961. (IF: 6.8, 一区Top）

2. Hao Cui, Guodong Zhang, Liyuan Zhang, Shilong Sun, Kang Yang, Aixin Gen, Penfeng Wang, Hui Wang, Qing-Qing Zhou, Hongmei Li, Yadong Chen, Yuqin Yao, Tao Lu*, Lei Zhang*, Yong Zhu*. Discovery of N-phenyl-5-propyl-1H-pyrazole-3-carboxamide, with selective inhibition and degradation of HDAC6 for the treatment of acute liver injury. Journal of Medicinal Chemistry. 2025, 68(1): 531-554. (IF: 6.8, 一区Top）

3. Hao Cui^#, Qianqian Hong^#, Ran Wei, Hongmei Li, Chunyang Wan, Xin Chen, Shuang Zhao, Haizhi Bu, Bingxu Zhang, Dexiao Yang, Tao Lu*, Yadong Chen*, Yong Zhu*. Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics. European Journal of Medicinal Chemistry. 2022 5(229): 114049.（IF: 5.9, 1区）

4. Hao Cui, Jingkun Huang, Yan Lei, Quanwei Chen, Zan Hu, Jiaqi Niu, Ran Wei, Kang Yang, Hongmei Li, Tao Lu*, Yong Zhu*, Yatian Huang*. Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer. European Journal of Medicinal Chemistry. 2022 5(229): 114082.（IF: 5.9, 1区）

5. Hao Cui^#, Zan Hu^#, Kang Yang, Jingkun Huang, Yichao Wu, Quanwei Chen, Ran Wei, Penfeng Wang, Hui Wang, Tao Lu*, Yuqin Yao*, Yong Zhu*. Design and synthesis of highly TRAIL expression HDAC inhibitors based on ONC201 to promote apoptosis of colorectal cancer. European Journal of Medicinal Chemistry. 2022 10(238): 114568.（IF: 5.9, 1区）

联系方式：

E-mail：cuih1008@ahmu.edu.cn

地址：安徽省合肥市安徽医科大学药学科学学院