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许瑞

发布时间:2025-03-26    来源:



许瑞,男,1993年06月生,安徽全椒人,中共党员,口腔颌面外科学博士(武汉大学),安徽医科大学校聘副教授,硕士研究生导师,安徽医科大学口腔医学院高层次引进人才(四类)。2019年取得口腔临床医学硕士学位(导师:邹多宏 教授),2023年取得口腔颌面外科学博士学位(导师:陈刚 教授)。主要研究方向为:纳米技术在口腔鳞癌诊治及口颌面软硬组织修复中的应用。主持省厅级、校级等各类科研项目4项,以第一/通讯作者(含共同)在《Biomaterials》、《Analytical Chemistry》、《Chemical Engineering Journal》、《Journal of Controlled Release》、《Acta Biomaterialia》、《Advanced Healthcare Materials》等国际期刊上发表SCI论文15篇。《Journal of Nanobiotechnology》、《International Journal of Oncology》等国际期刊审稿人。指导硕士研究生获得国家奖学金(2025)。


一、研究方向
1.生物纳米材料用于口腔鳞癌诊治
2.细胞外囊泡功能化材料用于口腔软硬组织修复
3.细胞外囊泡介导口腔鳞癌免疫逃逸机制


二、科研项目
1.安徽省教育厅科学研究项目,2025AHGXZK40288,口腔鳞癌PD-L1+外泌体通过整合素-LECs轴构建转移前免疫耐受微环境的机制研究,2026/1-2027/12,10万,主持,在研。
2.安徽医科大学基础与临床合作研究提升计划资助项目,2023xkjT046,弓形虫外泌体疫苗联合PD-1单抗提高肿瘤免疫治疗疗效的研究,2024/1-2026/12,20万,主持,在研。
3.安徽省转化医学研究院科研基金培育项目,2023zhyx-C90,基于弓形虫外泌体的靶向药物递送载体构建及其在口腔鳞癌免疫治疗中的应用,2024/1-2026/12,8万,主持,在研。
4.安徽医科大学2023年4类人才引进科研启动经费项目,40万,主持,在研。


三、代表性论文(影响因子及分区均以发表当年计)
1.Xu R#(第一作者), Xu Z-W#, Si Y-C, et al., Wu Z-Y*, Zhang G-L*. Oxygen vacancy defect-induced activity enhancement of Gd doping magnetic nanocluster for oxygen supplying cancer theranostics. ACS Appl. Mater. Interfaces, 2020, 12(33): 36917–36927.(IF: 9.229,中科院一区Top)
2.Xu R#(第一作者), Yu Z-L#, Liu X-C, et al., Wu M*, Chen G*. Aptamer-assisted traceless isolation of PD-L1-positive small extracellular vesicles for dissecting their subpopulation signature and function. Anal. Chem, 2023, 95(2): 1016–1026.(IF: 6.7,中科院一区Top,自然指数期刊)
3.Xu R#(第一作者), Zhao Z-Y#, Zhou L-X#, et al., Cao Y*, Pan Z*, Zou D-H*. GelMA-based moldable and rapid-curable osteogenic paste inspired by ceramic craft for alveolar bone defect regeneration. Int. J. Biol. Macromol, 2024, 283: 137058.(IF: 8.5,中科院一区Top)
4.Wang S-M#, Wang D#, Shen Y-Q, et al., Jia F*, Zheng X-Y*, Wen H-Q*, Xu R*(末位通讯). Isolation and detection strategies for decoding the heterogeneity of extracellular vesicles. Chem. Eng. J, 2025, 507: 160234. (IF: 13.2,中科院一区Top)
5.Zhao L-X#, Sun Q#, Wang C, et al., Xu W-H*, Xu R*(末位通讯). Toxoplasma gondii-derived exosomes: a potential immunostimulant and delivery system for tumor immunotherapy superior to toxoplasma gondii. Int. J. Nanomed, 2024, 19: 12421-12438.(IF: 6.5,中科院二区Top)
6.Zhao L-X#, Wang E-T#, Jia W-H, et al., Xu W-H*, Xu R*(末位通讯). Emerging Salivary Exosome Nanodiagnostics for Early Oral Squamous Cell Carcinoma: Platforms, Biomarkers, and Future Perspectives. Int. J. Nanomed, 2026, 21:1-30.(IF=6.5,中科院二区Top)
7.Shen Y-Q#, Sun L#, Wang S-M, et al., Zheng X-Y*, Xu R*(末位通讯). Exosomal integrins in tumor progression, treatment and clinical prediction (Review). Int. J. Oncol, 2024, 65(6): 118.(IF: 4.9,中科院三区)
8.Shao L-M#, Zhang H-R#, Sun L#, et al., Xu R*(共同通讯), Jia F*. Responsive degradable bottlebrush polymers enable drugs with superior efficacy and minimal systemic toxicity. Adv. Healthc. Mater, 2025, 14(6): 2405202.(IF: 9.6,中科院二区Top)
9.Chen X#, Sun L#, Ning Y-J, et al., Guo Y-C*, Xu R*(共同通讯), Wu J-W*. Injectable polydopamine/curcumin dual-modified polylactic acid/polycaprolactone coaxial staple fibers for chronotropic treatment of oral squamous cell carcinoma. Int. J. Biol. Macromol, 2025, 292: 139094.(IF: 8.5,中科院二区Top)
10.Xiao J-M#, Zhang G-L#, Xu R#(共同一作), et al., Wu Z-Y*, Zou D-H*. A pH-responsive platform combining chemodynamic therapy with limotherapy for simultaneous bioimaging and synergistic cancer therapy. Biomaterials, 2019, 216: 119254.(IF: 10.317,中科院一区Top)
11.Liu X-C#, Zhang H-J#, Xu R#(共同一作), et al., Tian Z-Q*, Yu Z-L*, Chen G*. A NIR-II quantum dot-assisted dual-color imaging strategy enables simultaneous tracking of two subtypes of extracellular vesicles in vivo. Chem. Eng. J, 2024, 492: 152242.(IF: 13.2,中科院一区Top)
12.Liu J#, Yu Z-L#, Xu R#(共同一作), et al., Chen G*, Tian Z-Q*. The second near-infrared window quantum dot-based fluorescence anisotropy probes for separation-free, sensitive and rapid detection of small extracellular vesicle PD-L1 in plasma samples. Sens. Actuators B Chem, 2023, 376: 132962.(IF: 8.0,中科院一区Top)


四、联系方式
E-mail: dentistxr@fy.ahmu.edu.cn
ResearchGate: https://www.researchgate.net/profile/Rui-Xu-172?ev=hdr_xprf